Also, IL-1 released from HNSCC cells has been shown to stimulate COX-2 production by CAFs [124] that correlated with lymphangiogenesis [125] and E-cadherin regulation, important factors for epithelial-to-mesenchymal transition (EMT) development [126], and increased risk of distant metastases [127]. This evidence concerns the gene IL1B and head and neck squamous cell carcinoma.