NF-κB is considered a key factor in the regulation of the inflammatory infiltrate observed in the TME [105] and has been associated with the acquisition of a malignant phenotype of HNSCC, as is associated with tumor angiogenesis [106], EMT [107], invasion [108, 109] and metastasis [110]. The gene discussed is NFKB1; the disease is head and neck squamous cell carcinoma.