In addition, inactivation of NF-κB in HNSCC suppressed cell survival and expression of IL-1α, IL-6, CXCL8 and GM-CSF in a murine model of head and neck cancer [111] and its aberrant expression is associated with poor prognosis in solid cancers [112]. This evidence concerns the gene NFKB1 and head and neck squamous cell carcinoma.