IL-1α expression also correlated with different genes that have been associated with metastasis, particularly MMP-9 (a matrix metalloproteinase associated with EMT), PGE2 (a product of COX-2 activation associated with metastases of OSCC), VEGF (the most important angiogenic factor in HNSCC) and CXCL8 [100]. This evidence concerns the gene VEGFA and head and neck squamous cell carcinoma.