Depletion of fibroblast activation protein (FAP)-positive CAF in murine models has been shown to enhance anti-tumour immunity [111]; Duperret et al. [112] used a DNA vaccine targeting FAP, which induced CD8+ and CD4+ T-cells and synergised with other tumour antigen-specific DNA vaccines to enhance anti-tumour immunity. Here, CD4 is linked to neoplasm.