• Known to complex with OCT4 and control downstream embryonic genes including NANOG [73]. • Involved in cell proliferation, migration, invasion, stemness, tumorigenesis and anti-apoptosis, and chemoresistance in HNSCC [68]. • Associated with surviving expression in ACC patients [129]. • Correlate positively with radiochemoresistance and poor prognosis in HNSCC patients [68, 71]. This evidence concerns the gene POU5F1 and head and neck squamous cell carcinoma.