IL1B and neoplasm: On the other hand, and consistent with the dual role of this cytokine, Dantas et al. [31] observed how IL-1β immunostaining was significantly higher in metastases of oral carcinomas and lymph nodes than in squamous epithelium of tumor resection margins; while Singh et al. [32] described how the immunostaining for IL-1β in non-metastatic oral carcinomas was weak in more than half of the cases.