In relation to IL-8, the highest mean of positive cells was observed in leukoplakias (413.87 ± 250.789 cells/field) followed by normal oral mucosa (389.80 ± 84.507 cells/field), OSCC (255 ± 193.90 cells/field), and finally OLP (230.02 ± 227.67 cells/field) (p = 0.046) (Table 1, Figure 2). This evidence concerns the gene CXCL8 and oral lichen planus.