Jenkins et al. [34] assessed the intensity of the NF-κB primary transcription factor and IL-8 expression in samples of esophageal adenocarcinoma, Barrett esophagitis (as premalignant precursor lesion), and squamous tissue next to these lesions and observed IL-8 diminish, similar to results obtained in the study. The gene discussed is NFKB1; the disease is esophageal adenocarcinoma.