The median (IQR) scores for stress (PSS-10), anxiety (GAD-7), depression (PHQ-9), somatic symptoms (PHQ-15), jaw functional limitation (JFLS), and parafunctions (OBC) in the common homozygous and rare homozygous combined with the heterozygous genotypes of the HTR2A (rs9316233), HTR3A (rs1062613), HTR3B (rs1176744), SERT (5-HTTLPR), and COMT (rs4680) polymorphisms in 117 individuals with temporomandibular disorder myalgia. The gene discussed is COMT; the disease is depressive disorder.