The IL-1 agonist receptor, IL-1R1, is also overexpressed in OSCCs and, together with IL-1β, was shown to promote cancer growth and metastasis by upregulating CXCR4, which could be reversed by inhibiting IL-1R1 by overexpressing the interleukin 1 receptor antagonist (IL-1RA) [13]. This evidence concerns the gene IL1B and cancer.