Here, Li et al., observed increased abundance of CD15+ neutrophils in HPV-negative compared to HPV-positive OSCC, as well as finding that high levels of neutrophils correlated with poor 5-year survival, increased lymph node metastasis and were an independent prognostic factor for OSCC [24]. The gene discussed is FUT4; the disease is metastatic malignant neoplasm in the lymph nodes.