FOXP3 and neoplasm: There may be a discourse between the numbers of circulating leukocytes and those recruited to the tumour micro-environment particularly for lymphocytes, as it appears that HPV-positive OPSCC contain greater numbers of specific subsets (CD8+ T cells, CD20-B cells and FoxP3+Treg) than their HPV-negative counterparts that are also associated with overall improved survival in HPV-positive OPSCC [5–7, 37, 40, 41].