Additionally, in a subgroup of hr-HPV-associated HNSCC, the p53 function is blocked by viral E6 oncoprotein through ubiquitin-protein ligase E3A (UBE3A) also known as E6AP protein ligase and p53 is degraded through proteasome pathway and with cysteine/histidine-rich 1 (CH1) domain of p300 to prevent p53 acetylation [39]. This evidence concerns the gene UBE3A and head and neck squamous cell carcinoma.