CASP8 and cancer: Studies have also shown that mutations in CASP-8 namely R417X (C>T), R218Q (G>A), G310D (G>A), G310D (G>A), D200fs (del TATT frameshift deletion at exon 4), E204X (G>T), Q225X (C>T), T258fs (C>T) and L428Q (T>A) affect functions of CASP-8 and these are positively correlated with cancer progression [155].