EGFR and neoplasm: Several therapeutic modalities for GBM in clinical trials include monoclonal antibodies targeting Epidermal Growth Factor Receptor (EGFR) (alone or conjugated with other drugs), chemotherapeutic agents (procarbazines, hydroxyureas, irinotecan, erlotinib, cyclophosphamide, and mTOR inhibitor), tumor treating fields (TTF) therapy, immunotherapies (vaccination, adoptive cell therapy, and immunostimulants), epigenetic therapy, oncolytic virus therapy, and gene therapy (11, 12).