In addition to the finding described above, in airway allergic inflammation and fibrotic processes, the DNAhsp65 diminished the Th2 response and IL-4 and IL-5 cytokine releases, leading to increased expression of IFN- and IL-22, which is related to the inhibition of inflammatory monocytes in allergy and decreases the deposition of ECM in fibrotic process. The gene discussed is IL4; the disease is allergic disease.