For example, in the HIV and influenza model, combined delivery of DNA vaccines with plasmids encoding a mucosal chemokine, CCL25, was found to increase antigen-specific responses in the lung and mesenteric lymph nodes, and also increase antigen-specific CD4+, CD8+ T-cell responses as well as IgA responses at the mucosal sites (122). This evidence concerns the gene CD8A and influenza.