The nine downregulated C/D snoRNAs represented 3.6% of the expressed C/D snoRNAs and were all part of the highly duplicated SNORD113-SNORD114 families embedded within the introns of lncRNA MEG8, which was previously linked to pancreatic and lung cancer epithelial to mesenchymal transition (EMT) (42,43). The gene discussed is MEG8; the disease is lung carcinoma.