The top 10 enriched pathways were involved in metabolism (arachidonic acid metabolism, apelin signaling pathway, peroxisome proliferator-activated receptors (PPAR) signaling pathway, and cGMP-PKG signaling pathway), contractile function (cardiac muscle contraction, adrenergic signaling in cardiomyocytes, cAMP signaling pathway, and calcium signaling pathway), cardiac remodeling (dilated cardiomyopathy and hypertrophic cardiomyopathy). The gene discussed is APLN; the disease is hypertrophic cardiomyopathy.