In 2003, Wang et al. (21) revealed that the 21bp deletion in exon 11 of MEF2A was co-isolated from the patient with premature coronary heart disease in a general pedigree, and MEF2A has become the first identified autosomal dominant genetic variation in the risk of coronary heart disease (named ADCAD1). This evidence concerns the gene MEF2A and coronary artery disorder.