So far, abundant studies have demonstrated that dysfunction of lncRNAs is associated with the pathogenesis and progression of a broad range of diseases including cardiovascular disease (11), examples of this include cyclin-dependent kinase inhibitor 2B (CDKN2B) antisense RNA 1 (ANRIL), which have been implicated in atherosclerosis (12), and metastasis associated lung adenocarcinoma transcript 1(MALAT1), which has been shown to stimulate vascular growth in vivo and drive the proliferation of migratory endothelial cells in vitro (13). The gene discussed is MALAT1; the disease is atherosclerosis.