AKT1 and neoplasm: The down-regulation of miR-99b and the up-regulation of its target gene IGF-1R may over-induced the PI3K-AKT signaling pathway, leading to abnormal cell proliferation (Li et al., 2015); miR-99b also attenuates tumor cell migration and invasion by down-regulating the PI3K/AKT/mTOR signaling pathway, providing a therapeutic approach for tumor therapy (Li et al., 2019).