Aberrant activation of JAK-STAT is encountered in many immune-mediated diseases (Jamilloux et al., 2019), including rheumatoid arthritis (RA) (Malemud, 2018), systemic lupus erythematosus (SLE) (Goropevšek et al., 2017), psoriatic arthritis (PsA) (Fiocco et al., 2014), psoriasis (Kwatra et al., 2012), inflammatory bowel disease (IBD) (Salas et al., 2020), Crohn’s disease, ulcerative colitis (Rogler, 2020), discoid lupus erythematosus (DLE), and dermatomyositis (DM) (Kahn et al., 2018). The gene discussed is SOAT1; the disease is dermatomyositis.