In RA pathology, SOCSs and PIASs are dysfunctional (Malemud, 2016), and experimental overexpression of SOCS3 in RA synovial tissue represses the inflammation (Shouda et al., 2001; Mahony et al., 2016; Silvagni et al., 2021). Here, SOCS3 is linked to rheumatoid arthritis.