The potential pathways, mechanisms, and bioprocess of the pyroptosis-related genes signature were analyzed based on GSEA, which revealed those genes regulated both the tumor development and immune response, centrally including NOD-like receptor signaling pathway, T-cell receptor signaling pathway, WNT signaling pathway, regulation of autophagy, MAPK signaling pathway, spliceosome, VEGF signaling pathway and pathways in cancer (Figure 10; Supplementary Table S4). Here, VEGFA is linked to cancer.