Research on inflammatory signaling in glaucoma pathogenesis has also identified other ion channels located at the surface of RGCs, such as Transient Receptor Potential Vanilloid isoform 4 (TRPV4) and Pannexin-1 (Panx1), that act as potential sensors and effectors of mechanical strain, ischemia, and inflammatory responses. Here, PANX1 is linked to glaucoma.