In mouse and human neuronal cells, cytoplasmic mislocalization and aggregation of transactive response (TAR) DNA-binding protein-43 (TDP-43) disrupts nuclear pore complexes and furthermore nucleocytoplasmic transport in amyotrophic lateral sclerosis and frontotemporal dementia (ALS and FTD) disease spectrum (Chou et al., 2018). Here, TARDBP is linked to amyotrophic lateral sclerosis.