TARDBP and frontotemporal dementia: In mouse and human neuronal cells, cytoplasmic mislocalization and aggregation of transactive response (TAR) DNA-binding protein-43 (TDP-43) disrupts nuclear pore complexes and furthermore nucleocytoplasmic transport in amyotrophic lateral sclerosis and frontotemporal dementia (ALS and FTD) disease spectrum (Chou et al., 2018).