From the proportion of various metabolites shown in Figures 10C,D, we were able to find some key differentially expressed metabolic enzymes, such as hexokinases (HKs), phosphoglycerate kinase (PGK), pyruvate kinases (PK), and lactate dehydrogenase (LDH), which have been found to be closely related to tumor aerobic glycolysis (Zhang et al., 2018; Shi et al., 2019; Yeung et al., 2019). This evidence concerns the gene PRKG1 and neoplasm.