However, more recently published studies showed that TXNIP is extensively related to varieties of chronic inflammation in categories of different diseases, such as Alzheimer’s diseases and pancreatic cancer (Bechard et al., 2020; Zhang et al., 2021b), which suggests that TXNIP might be a promising vital meditator in the complex signal conduction network among oxidative stress, mitochondrial stress, ROS accumulation, and NLRP3 inflammasome-induced pyroptosis. Here, TXNIP is linked to early-onset autosomal dominant Alzheimer disease.