TRIM59 directly induces the ubiquitination of ABHD5, leading to its proteasome-dependent degradation, activating the NLRP3 inflammasome signaling pathway, and promoting the secretion of IL-1β by macrophages; As the final result, exosomal TRIM59 facilitates lung cancer growth and metastasis. The gene discussed is ABHD5; the disease is lung carcinoma.