HMGB1 and Hyperglycemia: Previous studies have indicated that MSC-Exo-derived miR-126 can suppress hyperglycemia-induced inflammation by down-regulating high mobility group box-1 (HMGB1) protein, which can bind to TLR2, TLR4, and inflammasomes then help activate the NLRP3 pathway (Zhang et al., 2019c).