Currently, numerous studies have revealed that NLRP3 inflammasome has a crucial role in the pathogenesis of many diseases (Koka et al., 2017; Huang et al., 2021), such as cancer (Bruchard et al., 2013), cardiovascular diseases (Liu et al., 2018a), and metabolic diseases (Sharma and Kanneganti, 2021). Here, NLRP3 is linked to metabolic disease.