Currently, numerous studies have revealed that NLRP3 inflammasome has a crucial role in the pathogenesis of many diseases (Koka et al., 2017; Huang et al., 2021), such as cancer (Bruchard et al., 2013), cardiovascular diseases (Liu et al., 2018a), and metabolic diseases (Sharma and Kanneganti, 2021). The gene discussed is NLRP3; the disease is cancer.