Since that discovery in 2003, dominant mutations in Tyrosyl- (YARS), Alanyl- (AARS), Histidyl- (HARS), Tryptophanyl- (WARS), and possibly methionyl- (MARS) tRNA synthetases have been associated with forms of CMT (Jordanova et al., 2006; Latour et al., 2010; Gonzalez et al., 2013; Vester et al., 2013; Tsai et al., 2017). This evidence concerns the gene HARS1 and Charcot-Marie-Tooth disease.