PI3K/Akt/mTOR signaling pathway was necessary for tumor cells’ survival (Khan et al., 2013; Riquelme et al., 2016; Chen et al., 2018; Liu et al., 2020; Chen et al., 2021) (e.g., breast cancer (Yin et al., 2017; Nunnery and Mayer, 2020), head and neck cancer (Marquard and Jücker, 2020), and lung cancer (Tan, 2020)). The gene discussed is AKT1; the disease is head and neck cancer.