These results indicated that high expression of SCG2 might promote M0 macrophages polarize to M2 and eventually differentiate into TAMs, enhancing tumor cell invasion, metastasis, angiogenesis, and inhibiting the anti-tumoral immune surveillance (Kim and Bae, 2016), predict a worse prognosis of CRC patients (Waniczek et al., 2017). Here, SCG2 is linked to neoplasm.