IL6 and neoplasm: The tumor related pathways involved in tumorigenesis, tumor invasion, and metastasis included “Kras signaling up,” “Hedgehog signaling,” “Notch signaling,” “Wnt beta catenin signaling,” “TGF beta signaling,” “Epithelial mesenchymal transition,” and “Angiogenesis.” The inflammatory and immune related pathways included “Complement,” “IL2 STAT5 signaling,” “Inflammatory response,” “IL6 JAK STAT3 signaling,” and “Allograft rejection.” A summary of the enrichment results is shown in Supplementary Figure S3.