PDCD1 and hyperinsulinemic hypoglycemia, familial, 4: Upregulation of PD-1 and Tim-3 was associated with the poor prognosis of CRC patients in stage I-III (Kuai et al., 2020), and high expression of TIGIT was associated with advanced TNM stage and poor DFS in CRC patients with mismatch repair deficiency (Zhou et al., 2020).