SCG2 and metastatic malignant neoplasm in the lymph nodes: A univariate Cox survival analysis based on TCGA database indicated that TNM stage (p = 3.6e-04), Invasion depth (p = 0.031), Lymph node metastasis (p = 0.002), distant metastasis (p = 4.96e-07), and SCG2 expression (p = 0.008) were significant risk factors for overall survival (Table 1).