Upregulation of PD-1 and Tim-3 was associated with the poor prognosis of CRC patients in stage I-III (Kuai et al., 2020), and high expression of TIGIT was associated with advanced TNM stage and poor DFS in CRC patients with mismatch repair deficiency (Zhou et al., 2020). The gene discussed is HAVCR2; the disease is colorectal carcinoma.