Using the K-nearest-neighbor–based network graph drawing layout (KNetL) (Tang et al., 2021), our analysis suggests that low percentages of CD8 effector T-cells (TEFF) cells at baseline could predict irAEs arthritis, that more CD4 TH2 cells were associated with onset of pneumonitis, and that patients with thyroiditis had more CD4 TH17 cells before treatment with ICIs was initiated than those who did not develop this irAE (submitted manuscript). This evidence concerns the gene CD4 and Arthritis.