We further verified that the mutation rates of TP53, PIK3CA, and GATA3 followed the patterns of BC-ImH > BC-ImM > BC-ImL, BC-ImM > BC-ImL > BC-ImH, and BC-ImH < BC-ImM < BC-ImL, respectively, in METABRIC, which involved targeted exome sequencing data (Figure 6B). Here, PIK3CA is linked to breast cancer.