Meanwhile, the ratios of immunostimulatory over immunosuppressive signatures (CD8+/CD4+ regulatory T cells), which were the base-2 log-transformed values of the geometric mean expression levels of all marker genes of CD8+ T cells divided by those of CD4+ regulatory T cells, were the highest in BC-ImH and the lowest in BC-ImL (one-tailed Mann–Whitney U test, p < 0.05) in these datasets (Figure 2B). Here, CD8A is linked to breast cancer.