INS and cancer: Moreover, 72 target mRNAs were used to perform functional and pathway enrichment analyses, and the results indicated that these target genes were enriched in the cellular response to glucocorticoid stimulus, skeletal system development, embryonic eye morphogenesis, negative regulation of cell differentiation, rhythmic process, insulin signaling pathway, molecules associated with elastic fibers, and transcriptional misregulation in cancer (Figure 7B).