With the exception of MMP-9 mRNA in OVCAR4 cells, CIS and PTX both significantly increased the expression of MMP-2, -9 and -14 mRNAs and concurrently increased the expression of three CSC markers (OCT4A, EpCAM, CD133), associated with chemoresistance in the cancer cell lines. This evidence concerns the gene PROM1 and in situ carcinoma.