The main objective of this study was to compare the therapeutic effects of GKRS on ALK-positive patients with EGFR-positive and wild type patients, and to compare and verify the overall survival rate, incidence of neurological death, and development of new intracranial lesions after GKRS with and without driver gene mutations, as well as local tumor control and treatment-related complications caused by GKRS. Here, ALK is linked to neoplasm.