To identify better treatment targets of keloid, this study used WGCNA analysis, differential expression analysis, and degree algorithm and screened out 10 hub genes associated with keloid fibroblast from the GSE145725 dataset, including BMP4, MSX1, HAND2, TBX2, SIX1, IRX1, EDN1, DLX5, MEF2C, and DLX2. The gene discussed is SIX1; the disease is keloid.