Nevertheless, no association between BMP2 and BMP4 genetic variations (rs1049007, rs235768, and rs17563) and the risk of CHD was reported by Li FF et al. 106 Variations in the NPPA gene, which encodes the ANP precursor, are correlated with hypertension, stroke, coronary artery disease, and heart failure. This evidence concerns the gene BMP4 and Hypertension.