TNF and neoplasm: Wen et al. showed that high and medium doses of Tiaopi Huxin recipe (TPHXR) decreased the expression of caveolin-1 (CAV-1), NF-κB p50, NF-κB p65, ICAM-1, VCAM-1, tumor necrosis factor-α (TNF-α), IL-6, and interleukin-1β (IL-1β) in the vasculature of ApoE(-/-) mice; decreased tumor TNF-α, IL-6, hypersensitive-CRP (hs-CRP), and IL-1β in mouse plasma; promoted eNOS phosphorylation; increased NO level; and improved endothelium-dependent vasodilation [101].