VEGFA and heart failure: Wang et al. [96] demonstrated that the herbal compound Tongxinluo (TXL) significantly increased myocardial capillary density and alleviated oxidative stress injury in heart failure by inhibiting the expression of NOX-4 and upregulating cardiac nitrite content and the protein expression of vascular endothelial growth factor (VEGF), p-VEGFR2, p-phosphoinositide 3-kinase (p-PI3K), p-AKT, (p-eNOS), andh oxygenase-1 (HO-1).