The activation of two main biological approaches can form perforin and induce pyroptosis, like caspase 1/4/5/11-regulated gasdermin D- (GSDMD-) dependent activation and caspase 3-regulated gasdermin E- (GSDME-) dependent activation, which can lead to the release of inflammatory mediators and strengthen the tumor-killing effect of CD8+ T cells and other functional antitumor immune cells. Here, GSDMD is linked to neoplasm.