In other recent work, we targeted channels that play a role in cardiac arrhythmias and we identified more specific binding sites for lipid and lipid-like ligands, including ceramides that bind and modulate the HERG potassium channel (Miranda et al. 2021) and poly-unsaturated fatty acid derivatives that modulate the KCNQ1 potassium channel (Yazdi et al. 2021). This evidence concerns the gene KCNA3 and cardiac arrhythmia.