CHKA and breast cancer: Similarly, the result from trials reporting the KPS score improvement rate [28, 30–33, 36–38, 40–42, 47, 48, 52] illustrated that the cumulative Z-curve across the traditional boundary of 5% significance and cross the monitoring boundaries as well, indicating that CKI plus chemotherapy for patients with breast cancer could draw an encouraging conclusion on KPS score improvement rate before acquired information size of 3072 participants [55] (Figure 9).