NQO1 and hepatocellular carcinoma: It has been shown that quindoline and cryptolepinone, as well as N-trans-feruloyltyramine identified in S. acuta and S. rhombifolia hydro ethanolic extracts have a significant anti-proliferative activity on mouse hepatoma cells (Hepa 1c1c7) by inhibiting the quinone reductase activity [46].