For example, ursolic acid as a lipophilic pentacyclic triterpenoid exhibits anti-inflammatory properties via regulation of the NF-κB/NLRP3 inflammasome pathway and ameliorates osteoarthritis [37], celastrol as a pentacyclic triterpenoid quinone methide ameliorates MSU-induced gouty arthritis by inhibiting K63 deubiquitination of NLRP3 [38], and madecassoside is also reported to have anti-inflammation effect on MSU crystal-stimulated gouty arthritis via modulating NLRP3 [39]. This evidence concerns the gene NFKB1 and osteoarthritis.