We observed that the expression of NT5C2 (P=0.0055), NT5DC2 (P=0.027), and NT5DC3 (P=0.035) was closely correlated with tumor stage, suggesting that the expression of NT5C2, NT5DC2, and NT5DC3 increased significantly with the progression of HCC. The gene discussed is NT5C2; the disease is hepatocellular carcinoma.