Furthermore, multivariate Cox regression analysis indicated that diabetes treatment of oral medication only (HR = 0.152, 95%CI = 0.032–0.73, p=0.0036) or oral medication plus insulin (HR = 0.095, 95%CI = 0.019–0.462, p=0.019)), older age (HR = 1.076, 95% CI = 1.014–1.143, p=0.016), elevated glucose level (HR = 1.153, 95% CI = 1.038–1.28, p=0.0079), and increased SAA (HR = 1.007, 95% CI = 1.001–1.014, p=0.022) are independent prognostic factors (Figure 2(a)). This evidence concerns the gene INS and diabetes mellitus.