In this example, 16 DMSs in genes, such as CPT1A (Mendelson et al., 2017; Wahl et al., 2017; Dhana et al., 2018), ABCG1 (Mendelson et al., 2017; Wahl et al., 2017; Dhana et al., 2018), SLC7A11 (Mendelson et al., 2017; Wahl et al., 2017), RNF145 (Mendelson et al., 2017; Wahl et al., 2017), and SREBF1 (Mendelson et al., 2017; Wahl et al., 2017; Dhana et al., 2018) were reported to be associated with obesity-related phenotypes. The gene discussed is RNF145; the disease is obesity due to melanocortin 4 receptor deficiency.