Zhang et al. (2017) found in their analysis of the Han population that the rs1878406 TT/TC genotype could be a significant risk factor for severe multiple coronary artery lesions. Moreover, our results indicated that rs1878406 could change the binding affinity of regulatory motifs Myf_4. The above results of previous studies are consistent with our studies, suggesting that the C→T mutation in the EDNRA gene rs1878406 may influence the function of ET-1, thereby affecting the occurrence of atherosclerosis. This evidence concerns the gene EDN1 and atherosclerosis.