At the earlier exploration stage (2010–2013), some rising terms were identified with identification, promoter, chromatin, expression, enhancer, etc. However, at the rapid development stage (2014–2018), some new terms with association to biological functions and diseases emerged, such as DNA methylation, induction, suppression, gene regulation, oncogene, liver cancer, tumor initiating cell, ovarian cancer, therapeutic target, etc. At the stable-growth stage (2019–2020), some emerging topics were observed, such as interact, wnt, starbase, and myc. Here, MYC is linked to liver cancer.