Although other DEGs can also obtain enrichment pathways, for example, the up-regulated DEGs in glomerular samples are enriched in nicotinate and nicotinamide metabolism, basal cell carcinoma, renin secretion, etc. Down-regulated DEGs in renal tubule samples are enriched in prion diseases, S. aureus infection, pertussi, etc. Those enrichment analysis results were not statistically significant (Supplementary Material 3). The gene discussed is REN; the disease is prion disease.