REN and pertussis: Although other DEGs can also obtain enrichment pathways, for example, the up-regulated DEGs in glomerular samples are enriched in nicotinate and nicotinamide metabolism, basal cell carcinoma, renin secretion, etc. Down-regulated DEGs in renal tubule samples are enriched in prion diseases, S. aureus infection, pertussi, etc. Those enrichment analysis results were not statistically significant (Supplementary Material 3).