YTHDF1 was confirmed to induce the expression of lysosomal proteases by recognizing their m6A-marked mRNAs and increasing translation efficiency, which caused DCs to be unable constantly cross-present engulfed tumor neoantigens and then impeded the antigen-specific activation of CD8 + T cells (Han et al., 2019). The gene discussed is YTHDF1; the disease is neoplasm.