Deregulated COL4A1 was identified in lots of tumors, such as esophageal squamous cell carcinoma, laryngeal squamous cell carcinoma, hepatocellular carcinoma, and bladder cancer, etc. (Miyake et al., 2017; Chen et al., 2019; Liu et al., 2020; Zhong et al., 2020). The gene discussed is COL4A1; the disease is urinary bladder cancer.