The results indicated that anti-CD19 CAR-T cells might be gradually depleted under long-term antigen stimulation, while the cytotoxicity of anti-CD19 CAR-T cells was increased by miR155 and miR155 over-expression might be beneficial for the long-term anti-tumor function of anti-CD19 CAR-T cells (Figure 2D). The gene discussed is CD19; the disease is neoplasm.