Researches have shown that miR155 upregulation promotes the differentiation of naive CD4+ T cells into Th1 cells through the regulation of the IFN-γ signal (34), which is of great significance for T cells to exert anti-tumor function for the secretion of IFN-γ, TNF-α, IL-2 and other cytokines. This evidence concerns the gene IL2 and neoplasm.