KAT8 and breast carcinoma: For instance, KAT8 acetylates NRF2 to modulate anti-drug response in human non-small cell lung cancer (30); KAT8 acetylates A1B1 to promote breast cancer cell proliferation (31); It was also found that KAT8 can catalyze acetylation of the DNA binding domain of p53 in H1299 cells to induce cell apoptosis (29).