MAD2L1 and colonic neoplasm: In human colon cancer cell HCT116, STING was observed to downregulate the expression of proliferation-related genes BUB1 (Budding Uninhibited by Benzimidazoles related 1) and MAD2L1 (Mitotic Arrest Deficient 2-like 1), indicating that STING may also play a role in tumor suppression in cancer cells that lack cGAS expression (37).