Based on The Cancer Genome Atlas (TCGA) dataset containing 18 types of malignant tumors, some scholars have compared the changes in the expression of critical molecules in the cGAS/STING signaling pathway between malignant and normal control tissues, including MB21D1 encoding cGAS and TMEM173 encoding STING, as well as TBK1 and IRF3. This evidence concerns the gene IRF3 and cancer.