STING1 and neoplasm: It has been demonstrated that the inhalation of phosphatidylserine-coated liposomes loaded with cGAMP (NP-cGAMP), a STING agonist, in mouse models of lung metastases can rapidly distribute NP-cGAMP to the lungs and stimulate STING signal transduction in antigen-presenting cells, promoting the production of type I IFN, and the synergistic effect of NP-cGAMP and graded IR (8 Gy x 3) can suppress tumor metastasis at the site of radiotherapy and lung metastasis without radiotherapy (101).