It has been shown that under conditions of chronic STING activation, high ISG expression in cancer cells may impose a transcriptional state on the tumor that is used to respond to aberrant dsRNA accumulation due to increased sensor levels (MDA5, RIG-I, and PKR), suggesting that cGAS may act as an indirect sensor of dsRNA and exert anti-tumor effects (16). The gene discussed is STING1; the disease is neoplasm.