TBK1 and cancer: Based on The Cancer Genome Atlas (TCGA) dataset containing 18 types of malignant tumors, some scholars have compared the changes in the expression of critical molecules in the cGAS/STING signaling pathway between malignant and normal control tissues, including MB21D1 encoding cGAS and TMEM173 encoding STING, as well as TBK1 and IRF3.