In two tumor models that employed a mouse SCC cell line (mSCC1) that was generated from methylcholanthrene-induced carcinoma and a mouse CT26 colon cancer cell line, research shows that mature CD11bmid Ly6C+ F4/80+ MHC class II+ macrophages can instantly migrate to the tumor site through a STING-dependent signaling pathway in the tumor microenvironment. Here, STING1 is linked to colonic neoplasm.