ISG15 and infection: Compared to the 0.3% FA diet, the IS additive diet stimulated pathways involved in heat shock proteins, glycolysis, mucus production, and skeletal muscle development, while it suppressed genes of innate immunity such as interferon-induced protein 44-like (ifi44), isg15, ccl4 and fth in the single infection (Supplementary File 3, sub-table T1).